Our Research

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Bioinformatics and Integrative Genomics

Group Leader : Dr Jason Wong
With the proliferation of biological data over the past decade, bioinformatics has become an indispensable tool in understanding biological processes.  The major focus of our research is to contribute to the understanding of the functional aspects of the human genome in health and disease through integrative analysis of the different levels of information encoded by the genome. Our research involves the application of methods in data mining and machine learning to a broad range of problems in genomics, proteomics and molecular evolution with particular focus on cancer biology. Our research group also extensively use mass spectrometry as a technique to study proteins and the proteome in relation of gene regulation and protein function. ...
Jason Wong

Cancer & Stem Cell Biology

Group Leader : Dr Jenny Wang
Genetic and epigenetic abnormalities enable cancer stem cells to hijack normal stem cell self-renewal mechanisms that multiply out of control, causing cancer. The major goal of the Cancer and Stem Cell Biology Group is to understand the mechanisms that regulate aberrant self-renewal and drug resistance of malignant stem cells, and to develop cancer stem cell-targeted therapies that are more effective and less toxic for patients with tumours ...
image - Lowy Research V1

Cancer Cell Development

Group Leader : Dr Karen MacKenzie
The Cancer Cell Development Group investigates molecular changes that promote cellular immortalisation (unrestricted replication of cancer cells) with the aim of determining new approaches to halting the replication of cancer cells. This research has broad implications for the treatment of many different cancers ...
Karen MacKenzie

Cancer Cell Immortality

Group Leader : Dr Jeremy Henson
Cellular immortality is a hallmark of cancer and provides a cancer-specific target for creating anti-cancer drugs with minimal side-effects. The Cancer Cell Immortality Group has developed the only specific biomarker and quantitative assay for the ALT (Alternative Lengthening of Telomeres) immortality mechanism, which now makes it possible to generate novel ALT-targeted therapeutics and diagnostics, as well as furthering our understanding of the ALT cellular immortality mechanism. ...
Dr Jeremy Henson

Coagulation in Cancer

Group Leader : Dr Vivien Chen
Our goal is to understand the processes that promote abnormal thrombosis, thus to be able to predict, prevent and treat thrombosis in clinical syndromes ...
Vivien Chen

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